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Arachidonate lipoxygenase 3
Symbols ALOXE3 ; ARCI3; E-LOX; eLOX-3; eLOX3
External IDs OMIM607206 MGI1345140 HomoloGene8013 GeneCards: ALOXE3 Gene
EC number,
RNA expression pattern
PBB GE ALOXE3 207708 at tn.png
PBB GE ALOXE3 222383 s at tn.png
More reference expression data
Species Human Mouse
Entrez 59344 23801
Ensembl ENSG00000179148 ENSMUSG00000020892
UniProt Q9BYJ1 Q9WV07
RefSeq (mRNA) NM_001165960 NM_011786
RefSeq (protein) NP_001159432 NP_035916
Location (UCSC) Chr 17:
8.1 – 8.12 Mb
Chr 11:
69.13 – 69.15 Mb
PubMed search [1] [2]

Epidermis-type lipoxygenase 3 is an enzyme that in humans is encoded by the ALOXE3 gene.[1]

The leukotrienes constitute a group of arachidonic acid-derived compounds with biologic activities suggesting important roles in inflammation and immediate hypersensitivity. These compounds are catabolized, in part, by lipoxygenases. Epidermis-type lipoxygenases, a distinct subclass within the multigene family of mammalian lipoxygenases, are novel isoenzymes isolated from human and mouse skin including human ALOX15B (MIM 603697), human and mouse ALOX12B (MIM 603741), mouse 8S-LOX, and mouse e-LOX-3.[supplied by OMIM][1]


Further reading[edit]