AM-087

From Wikipedia, the free encyclopedia
Jump to: navigation, search
AM-087
AM-087.png
Systematic (IUPAC) name
(6aR,10aR)-3-(2-methyl-6-bromohex-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Identifiers
CAS Number 152674-96-9 YesY
PubChem CID 10717065
ChemSpider 8892405 YesY
ChEMBL CHEMBL199561 YesY
Chemical data
Formula C23H33BrO2
Molar mass 421.410 g/mol
  (verify)

AM-087 (part of the AM cannabinoid series) is an analgesic drug which acts as a cannabinoid agonist.[1] It is a derivative of Δ8THC substituted on the 3-position side chain. AM-087 is a potent CB1 agonist with a Ki of 0.43nM, making it around 100x more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.[2]

See also[edit]

References[edit]

  1. ^ Martin, Billy R.; Compton, David R.; Semus, Simon F.; Lin, Sonyuan; Marciniak, Gilbert; Grzybowska, Jolanta; Charalambous, Avgui; Makriyannis, Alexandros (1993). "Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC". Pharmacology Biochemistry and Behavior. 46 (2): 295–301. doi:10.1016/0091-3057(93)90356-X. ISSN 0091-3057. 
  2. ^ Charalambous A, et al. Pharmacological evaluation of halogenated delta 8-THC analogs. Pharmacology, Biochemistry and Behaviour. 1991 Nov;40(3):509-12. PMID 1666915