AMG-1

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AMG-1
AMG-1.png
Systematic (IUPAC) name
(6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Identifiers
PubChem CID 10830874
ChemSpider 9006174 YesY
ChEMBL CHEMBL279147 YesY
Chemical data
Formula C23H30O2
Molar mass 338.482 g/mol
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AMG-1 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6nM at CB1 vs 3.1nM at CB2.[1]

References[edit]

  1. ^ Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753