AMG-1

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AMG-1
AMG-1.png
Systematic (IUPAC) name
(6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Identifiers
CAS Number 205746-46-9 YesY
PubChem CID 10830874
ChemSpider 9006174 YesY
ChEMBL CHEMBL279147 YesY
Chemical data
Formula C23H30O2
Molar mass 338.482 g/mol
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AMG-1 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6nM at CB1 vs 3.1nM at CB2.[1][2]

See Also[edit]

References[edit]

  1. ^ Papahatjis, Demetris P.; Nikas, Spyros P.; Kourouli, Therapia; Chari, Ravi; Xu, Wei; Pertwee, Roger G.; Makriyannis, Alexandros (2003). "Pharmacophoric Requirements for the Cannabinoid Side Chain. Probing the Cannabinoid Receptor Subsite at C1‘". Journal of Medicinal Chemistry 46 (15): 3221–3229. doi:10.1021/jm020558c. ISSN 0022-2623. 
  2. ^ Keimowitz, Alison R.; Martin, Billy R.; Razdan, Raj K.; Crocker, Peter J.; Mascarella, S. Wayne; Thomas, Brian F. (2000). "QSAR Analysis of Δ8-THC Analogues: Relationship of Side-Chain Conformation to Cannabinoid Receptor Affinity and Pharmacological Potency". Journal of Medicinal Chemistry 43 (1): 59–70. doi:10.1021/jm9902281. ISSN 0022-2623.