Angiomotin-like protein 1

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AMOTL1
Identifiers
Aliases AMOTL1, JEAP, angiomotin like 1
External IDs MGI: 1922973 HomoloGene: 43977 GeneCards: AMOTL1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301007
NM_130847

NM_001081395

RefSeq (protein)

NP_001287936
NP_570899
NP_570899.1

NP_001074864.1
NP_001074864

Location (UCSC) Chr 11: 94.71 – 94.88 Mb Chr 9: 14.54 – 14.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.[3][4]

Function[edit]

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y (Feb 2002). "JEAP, a novel component of tight junctions in exocrine cells". J Biol Chem. 277 (7): 5583–7. doi:10.1074/jbc.M110154200. PMID 11733531. 
  4. ^ a b "Entrez Gene: AMOTL1 angiomotin like 1". 

External links[edit]

Further reading[edit]