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  • Investigational
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RG7795 (ANA773 previously) is an antiviral drug candidate that as of 2015 had been in Phase II trials in hepatitis B.[1] It is an orally-available prodrug of isatoribine,[2] that was under development by Anadys Pharmaceuticals when it was acquired by Roche in 2011.[3] Its active metabolite is an [agonist]] of TLR7; activation of TLR7 causes secretion of endogenous type 1 interferons, which have antiviral activity.[2]


  1. ^ "RG 7795". AdisInsight. Retrieved 28 August 2017. 
  2. ^ a b Funk, E; Kottilil, S; Gilliam, B; Talwani, R (14 May 2014). "Tickling the TLR7 to cure viral hepatitis". Journal of translational medicine. 12: 129. doi:10.1186/1479-5876-12-129. PMC 4039542Freely accessible. PMID 24884741. 
  3. ^ "Inovio Goes It Alone on Hepatitis B Immunotherapy Vaccine as Roche Ends Collaboration". Genetic Engineering News. August 3, 2016.