ANAPC1

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ANAPC1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ANAPC1, APC1, MCPR, TSG24, anaphase promoting complex subunit 1
External IDs MGI: 103097 HomoloGene: 7414 GeneCards: ANAPC1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022662

NM_008569

RefSeq (protein)

NP_073153

NP_032595.2
NP_032595

Location (UCSC) Chr 2: 111.77 – 111.88 Mb Chr 2: 128.61 – 128.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.[3][4]

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).[4]

Interactions[edit]

ANAPC1 has been shown to interact with ANAPC5,[5][6] ANAPC4,[5][6] ANAPC2,[5][6] CDC27[5][6] and ANAPC7.[5][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene. 262 (1-2): 51–9. doi:10.1016/S0378-1119(00)00511-4. PMID 11179667. 
  4. ^ a b "Entrez Gene: ANAPC1 anaphase promoting complex subunit 1". 
  5. ^ a b c d e Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. England. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. 
  6. ^ a b c d e Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. UNITED STATES. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443Freely accessible. PMID 11076961. 

External links[edit]

Further reading[edit]