From Wikipedia, the free encyclopedia
Jump to: navigation, search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases ANAPC7, APC7, anaphase promoting complex subunit 7
External IDs MGI: 1929711 HomoloGene: 10512 GeneCards: ANAPC7
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ANAPC7
Genomic location for ANAPC7
Band 12q24.11 Start 110,372,900 bp[1]
End 110,403,730 bp[1]
RNA expression pattern
PBB GE ANAPC7 gnf1h00221 s at fs.png

PBB GE ANAPC7 gnf1h00220 at fs.png

PBB GE ANAPC7 gnf1h07410 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 12: 110.37 – 110.4 Mb Chr 12: 122.42 – 122.44 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.[5] Multiple transcript variants encoding different isoforms have been found for this gene.


This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[5]


ANAPC7 has been shown to interact with ANAPC1,[6][7] ANAPC4,[6] CDC27[6][8] and CDC20.[6][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196510 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029466 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7". 
  6. ^ a b c d Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. 
  7. ^ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443Freely accessible. PMID 11076961. 
  8. ^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806Freely accessible. PMID 10922056. 
  9. ^ Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557Freely accessible. PMID 18997788. 

External links[edit]

Further reading[edit]