Annexin A7

From Wikipedia, the free encyclopedia
  (Redirected from ANXA7)
Jump to navigation Jump to search
AliasesANXA7, ANX7, SNX, SYNEXIN, annexin A7
External IDsMGI: 88031 HomoloGene: 36149 GeneCards: ANXA7
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ANXA7
Genomic location for ANXA7
Band10q22.2Start73,375,101 bp[1]
End73,414,076 bp[1]
RNA expression pattern
PBB GE ANXA7 209860 s at fs.png

PBB GE ANXA7 201366 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 73.38 – 73.41 MbChr 14: 20.46 – 20.48 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.[5][6]

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. The selection of poly(A) signals is independent of the mRNA splicing pattern. ~Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.[6]


ANXA7 has been shown to interact with ALG2[7] and SRI.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138279 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021814 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Shirvan A, Srivastava M, Wang MG, Cultraro C, Magendzo K, McBride OW, Pollard HB, Burns AL (Jul 1994). "Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10". Biochemistry. 33 (22): 6888–901. doi:10.1021/bi00188a019. PMID 7515686.
  6. ^ a b "Entrez Gene: ANXA7 annexin A7".
  7. ^ Satoh, Hirokazu; Nakano Yoshimi; Shibata Hideki; Maki Masatoshi (Nov 2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochim. Biophys. Acta. Netherlands. 1600 (1–2): 61–7. doi:10.1016/S1570-9639(02)00445-4. ISSN 0006-3002. PMID 12445460.
  8. ^ Brownawell, A M; Creutz C E (Aug 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". J. Biol. Chem. UNITED STATES. 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. ISSN 0021-9258. PMID 9268363.

External links[edit]

Further reading[edit]