|Jmol-3D images||Image 1
|Molar mass||225.179 g/mol|
|Boiling point||480.1 °C (896.2 °F; 753.2 K)|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
AP-7 functions specifically as a NMDA recognition site blocker, in contrast with 7c-KYNA which acts as a glycine site modulation blocker.
AP-7 injected directly into the dorsal periaqueductal grey (DPAG) of rats produced an anxiolytic effect, whereas direct injection outside of the DPAG did not elicit anxiolytic effects. This suggests that a portion of systemically taken NMDA antagonist’s anxiolytic effects comes from the DPAG region of the brain, at least in rats.
The DPAG of the brain is thought to deal with fear-like defensive behavior via NMDA and glycine B receptors. These excitatory glutamate receptors work with the inhibitory GABA receptors to achieve equilibrium in the DPAG of the brain.
AP-7 has been known to cause muscle rigidity and catalepsy in rats following bilateral microinjections (0.02-0.5 nmol) into the globus pallidus and ventral-posterior portions of the caudate-putamen.
The optically pure D-(-)-2-amino-7-phosphonoheptanoic acid [D-AP7], has also been examined. In groups of hypoxia-treated rats, D-AP7 enhanced motility, exhibited anxiogenic-like effect and impaired consolidation in passive avoidance. Both AP-7 and D-AP7 function as potent, specific antagonists of the NMDA receptor.
- AP-7 2-amino-7-phosphonoheptanoate (a NMDA recognition site blocker)
- 7-cKYNA[derivative of KYNA], 7-chlorokynurenate (an NMDA glycine site antagonist)
- Meldrum B, Millan M, Patel S, de Sarro G (1988). "Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists". J. Neural Transm. 72 (3): 191–200. doi:10.1007/BF01243419. PMID 3047315.
- Guillemin GJ (April 2012). "Quinolinic acid, the inescapable neurotoxin". FEBS J. 279 (8): 1356–65. doi:10.1111/j.1742-4658.2012.08485.x. PMID 22248144.
- Guimarães FS, Carobrez AP, De Aguiar JC, Graeff FG (1991). "Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey". Psychopharmacology (Berl.) 103 (1): 91–4. doi:10.1007/BF02244080. PMID 1672463.
- Carobrez AP, Teixeira KV, Graeff FG (December 2001). "Modulation of defensive behavior by periaqueductal gray NMDA/glycine-B receptor". Neurosci Biobehav Rev 25 (7-8): 697–709. doi:10.1016/S0149-7634(01)00059-8. PMID 11801295.
- Car H, Wiśniewski K (March 1998). "The effect of baclofen and AP-7 on selected behavior in rats". Pharmacol. Biochem. Behav. 59 (3): 685–9. doi:10.1016/S0091-3057(97)00462-0. PMID 9512072.
- Turski L, Klockgether T, Turski WA, Schwarz M, Sontag KH (March 1990). "Blockade of excitatory neurotransmission in the globus pallidus induces rigidity and akinesia in the rat: implications for excitatory neurotransmission in pathogenesis of Parkinson's diseases". Brain Res. 512 (1): 125–31. doi:10.1016/0006-8993(90)91180-O. PMID 2159826.
- Nadlewska A, Car H, Wiśniewska R, Hoły Z, Wiśniewski K (2003). "Behavioral effects of D-AP7 in rats subjected to experimental hypoxia". Pol J Pharmacol 55 (3): 337–44. PMID 14506312.