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Available structures
PDBOrtholog search: PDBe RCSB
AliasesAP1G2, G2AD, adaptor related protein complex 1 gamma 2 subunit, adaptor related protein complex 1 subunit gamma 2
External IDsOMIM: 603534 MGI: 1328307 HomoloGene: 49141 GeneCards: AP1G2
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for AP1G2
Genomic location for AP1G2
Band14q11.2Start23,559,565 bp[1]
End23,568,070 bp[1]
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 14: 23.56 – 23.57 MbChr 14: 55.1 – 55.11 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.[5][6][7]

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein.[7]


AP1G2 has been shown to interact with NEDD4.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213983 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040701 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
  6. ^ Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (Oct 1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett. 435 (2–3): 263–8. doi:10.1016/S0014-5793(98)01083-7. PMID 9762922.
  7. ^ a b "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit".
  8. ^ Rost, Martina; Döring Tatjana; Prange Reinhild (Nov 2008). "gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway". J. Biol. Chem. United States. 283 (46): 32119–30. doi:10.1074/jbc.M802632200. ISSN 0021-9258. PMID 18772139.

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