AP1G2

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AP1G2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AP1G2, G2AD, adaptor related protein complex 1 gamma 2 subunit
External IDs MGI: 1328307 HomoloGene: 49141 GeneCards: AP1G2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282474
NM_001282475
NM_003917
NM_080545

NM_007455
NM_001303502

RefSeq (protein)

NP_001269403
NP_001269404
NP_003908

NP_031481.2
NP_001290431
NP_031481

Location (UCSC) Chr 14: 23.56 – 23.57 Mb Chr 14: 55.1 – 55.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.[3][4][5]

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein.[5]

Interactions[edit]

AP1G2 has been shown to interact with NEDD4.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J Biol Chem. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768. 
  4. ^ Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (Oct 1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett. 435 (2-3): 263–8. doi:10.1016/S0014-5793(98)01083-7. PMID 9762922. 
  5. ^ a b "Entrez Gene: AP1G2 adaptor-related protein complex 1, gamma 2 subunit". 
  6. ^ Rost, Martina; Döring Tatjana; Prange Reinhild (Nov 2008). "gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway". J. Biol. Chem. United States. 283 (46): 32119–30. doi:10.1074/jbc.M802632200. ISSN 0021-9258. PMID 18772139. 

External links[edit]

Further reading[edit]