AP1M1

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AP1M1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AP1M1, AP47, CLAPM2, CLTNM, MU-1A, adaptor related protein complex 1 mu 1 subunit
External IDs MGI: 102776 HomoloGene: 4017 GeneCards: AP1M1
RNA expression pattern
PBB GE AP1M1 gnf1h00787 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130524
NM_032493

NM_007456

RefSeq (protein)

NP_001123996
NP_115882

NP_031482.1
NP_031482

Location (UCSC) Chr 19: 16.2 – 16.25 Mb Chr 8: 72.24 – 72.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene.[3][4]

Function[edit]

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing.[5]

Interactions[edit]

AP1M1 has been shown to interact with VAMP4[6] and AP1G1.[7][8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (Jun 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655. 
  4. ^ Medigeshi GR, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P (Jan 2008). "AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin". Traffic. 9 (1): 121–32. doi:10.1111/j.1600-0854.2007.00672.x. PMID 17988225. 
  5. ^ "Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit". 
  6. ^ Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413Freely accessible. PMID 14608369. 
  7. ^ Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737. 
  8. ^ Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal of Cell Biology. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623Freely accessible. PMID 7593184. 

External links[edit]

Further reading[edit]