Adaptor-related protein complex 2, alpha 1

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AP2A1
Protein AP2A1 PDB 1gw5.png
Identifiers
Aliases AP2A1, ADTAA, AP2-ALPHA, CLAPA1, Adaptor-related protein complex 2, alpha 1, adaptor related protein complex 2 alpha 1 subunit
External IDs MGI: 101921 HomoloGene: 68997 GeneCards: AP2A1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014203
NM_130787

NM_001077264
NM_007458

RefSeq (protein)

NP_055018
NP_570603

NP_001070732.1
NP_031484.1
NP_001070732
NP_031484

Location (UCSC) Chr 19: 49.77 – 49.81 Mb Chr 7: 44.9 – 44.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.[3]

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.[4]

Interactions[edit]

Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2[5] and NUMB.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Robinson MS (April 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)". J Cell Biol. 108 (3): 833–42. doi:10.1083/jcb.108.3.833. PMC 2115374Freely accessible. PMID 2564002. 
  4. ^ "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". 
  5. ^ a b Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (September 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. England. 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088. 

External links[edit]

Further reading[edit]