APOL3

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APOL3
Identifiers
AliasesAPOL3, APOLIII, CG121, CG12_1, apoL-III, apolipoprotein L3
External IDsOMIM: 607253 HomoloGene: 129701 GeneCards: APOL3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 22: 36.14 – 36.17 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene.[3][4] Expressed in the gut, it has antibiotic properties.[5]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.[4]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128284 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
  4. ^ a b "Entrez Gene: APOL3 apolipoprotein L, 3".
  5. ^ Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, et al. (2021). "A human apolipoprotein L with detergent-like activity kills intracellular pathogens". Science. 373 (6552): eabf8113. doi:10.1126/science.abf8113. PMC 8422858. S2CID 235915023.

External links[edit]

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