ARFGEF1

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ARFGEF1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARFGEF1, ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
External IDs MGI: 2442988 HomoloGene: 4687 GeneCards: ARFGEF1
RNA expression pattern
PBB GE ARFGEF1 216266 s at fs.png

PBB GE ARFGEF1 202955 s at fs.png

PBB GE ARFGEF1 202956 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006421

NM_001102430

RefSeq (protein)

NP_006412

NP_001095900.1
NP_001095900

Location (UCSC) Chr 8: 67.17 – 67.34 Mb Chr 1: 10.14 – 10.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.[3][4][5]

Function[edit]

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.[5]

Interactions[edit]

ARFGEF1 has been shown to interact with FKBP2,[6] ARFGEF2[7] and PRKAR1A.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200. 
  4. ^ Morinaga N, Tsai SC, Moss J, Vaughan M (Nov 1996). "Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain". Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12856–60. doi:10.1073/pnas.93.23.12856. PMC 24010Freely accessible. PMID 8917509. 
  5. ^ a b "Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)". 
  6. ^ Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2322–7. doi:10.1073/pnas.2628047100. PMC 151339Freely accessible. PMID 12606707. 
  7. ^ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969Freely accessible. PMID 10716990. 
  8. ^ Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMC 149883Freely accessible. PMID 12571360. 

External links[edit]

Further reading[edit]