ARFIP2

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ARFIP2
Protein ARFIP2 PDB 1i49.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARFIP2, POR1, ADP ribosylation factor interacting protein 2
External IDsMGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ARFIP2
Genomic location for ARFIP2
Band11p15.4Start6,474,683 bp[1]
End6,481,479 bp[1]
RNA expression pattern
PBB GE ARFIP2 202109 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242854
NM_001242855
NM_001242856
NM_012402

NM_029802

RefSeq (protein)

NP_001229783
NP_001229784
NP_001229785
NP_036534

NP_084078

Location (UCSC)Chr 11: 6.47 – 6.48 MbChr 7: 105.63 – 105.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.[5][6][7]


Interactions[edit]

ARFIP2 has been shown to interact with Arf6,[8][9] ARF3,[6] ARF5[6][9] and RAC1.[5][9][10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030881 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b Van Aelst L, Joneson T, Bar-Sagi D (October 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". EMBO J. 15 (15): 3778–86. PMC 452058Freely accessible. PMID 8670882. 
  6. ^ a b c Kanoh H, Williger BT, Exton JH (April 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J Biol Chem. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142. 
  7. ^ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". 
  8. ^ D'Souza-Schorey, C; Boshans R L; McDonough M; Stahl P D; Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J. ENGLAND. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. ISSN 0261-4189. PMC 1170175Freely accessible. PMID 9312003. 
  9. ^ a b c Shin, O H; Exton J H (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. United States. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. ISSN 0006-291X. PMID 11478794. 
  10. ^ Tarricone, C; Xiao B; Justin N; Walker P A; Rittinger K; Gamblin S J; Smerdon S J (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. England. 411 (6834): 215–9. doi:10.1038/35075620. ISSN 0028-0836. PMID 11346801. 

Further reading[edit]

External links[edit]