ARFRP1

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ARFRP1
Identifiers
Aliases ARFRP1, ARL18, ARP, Arp1, ADP ribosylation factor related protein 1
External IDs MGI: 1923938 HomoloGene: 2425 GeneCards: ARFRP1
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ARFRP1
Genomic location for ARFRP1
Band 20q13.33 Start 63,698,642 bp[1]
End 63,708,025 bp[1]
RNA expression pattern
PBB GE ARFRP1 203174 s at fs.png

PBB GE ARFRP1 215984 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001165991
NM_001165992
NM_001165995
NM_029702

RefSeq (protein)

NP_001159463
NP_001159464
NP_001159467
NP_083978

Location (UCSC) Chr 20: 63.7 – 63.71 Mb Chr 2: 181.36 – 181.37 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.[5][6]

Function[edit]

The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.[6]

Interactions[edit]

ARFRP1 has been shown to interact with PSCD1.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101246 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038671 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem. 270 (51): 30657–63. doi:10.1074/jbc.270.51.30657. PMID 8530503. 
  6. ^ a b "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1". 
  7. ^ Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. doi:10.1074/jbc.274.14.9744. PMID 10092663. 

Further reading[edit]

External links[edit]