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Rho GTPase activating protein 4
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ARHGAP4 ; C1; RGC1; RhoGAP4; SrGAP4; p115
External IDs OMIM300023 MGI2159577 HomoloGene20403 GeneCards: ARHGAP4 Gene
RNA expression pattern
PBB GE ARHGAP4 204425 at tn.png
More reference expression data
Species Human Mouse
Entrez 393 171207
Ensembl ENSG00000089820 ENSMUSG00000031389
UniProt P98171 Q80Z68
RefSeq (mRNA) NM_001164741 NM_001162423
RefSeq (protein) NP_001158213 NP_001155895
Location (UCSC) Chr X:
153.91 – 153.93 Mb
Chr X:
73.89 – 73.92 Mb
PubMed search [1] [2]

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.[1][2] It has been shown to regulate cell motility and axonal outgrowth in vitro.[3]


  1. ^ Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P (Mar 1996). "An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells". Proc Natl Acad Sci U S A 93 (2): 695–9. doi:10.1073/pnas.93.2.695. PMC 40115. PMID 8570618. 
  2. ^ "Entrez Gene: ARHGAP4 Rho GTPase activating protein 4". 
  3. ^ Vogt, DL; Gray, CD; Young Ws, 3rd; Orellana, SA; Malouf, AT (2007). "ARHGAP4 IS A NOVEL RHOGAP THAT MEDIATES INHIBITION OF CELL MOTILITY AND AXON OUTGROWTH". Molecular and cellular neurosciences 36 (3): 332–42. doi:10.1016/j.mcn.2007.07.004. PMC 2111057. PMID 17804252. 

Further reading[edit]