ARHGAP5

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ARHGAP5
Protein ARHGAP5 PDB 2EE4.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARHGAP5, GFI2, RhoGAP5, p190-B, p190BRhoGAP, Rho GTPase activating protein 5
External IDs MGI: 1332637 HomoloGene: 907 GeneCards: ARHGAP5
RNA expression pattern
PBB GE ARHGAP5 217936 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001030055
NM_001173

NM_009706

RefSeq (protein)

NP_001025226
NP_001164

n/a

Location (UCSC) Chr 14: 32.08 – 32.16 Mb Chr 12: 52.52 – 52.57 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.[3][4]

Function[edit]

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.[4]

Interactions[edit]

ARHGAP5 has been shown to interact with Rnd1,[5] Rnd2,[5] Rnd3[5] and RHOA.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y (Feb 1996). "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking". J. Biol. Chem. 270 (52): 30919–26. doi:10.1074/jbc.270.52.30919. PMID 8537347.  Check date values in: |year= / |date= mismatch (help)
  4. ^ a b "Entrez Gene: ARHGAP5 Rho GTPase activating protein 5". 
  5. ^ a b c d Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. PMID 12842009. 

External links[edit]

Further reading[edit]