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Protein ARHGEF12 PDB 1txd.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases ARHGEF12, LARG, PRO2792, Rho guanine nucleotide exchange factor 12
External IDs MGI: 1916882 HomoloGene: 9088 GeneCards: ARHGEF12
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ARHGEF12
Genomic location for ARHGEF12
Band 11q23.3 Start 120,336,914 bp[1]
End 120,489,936 bp[1]
RNA expression pattern
PBB GE ARHGEF12 201333 s at fs.png

PBB GE ARHGEF12 201334 s at fs.png

PBB GE ARHGEF12 201335 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 120.34 – 120.49 Mb Chr 9: 42.96 – 43.11 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.[5][6][7]


Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor . The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.[7]

Clinical significance[edit]

This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia.[7]


ARHGEF12 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196914 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059495 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA (April 2000). "Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia". Proc Natl Acad Sci U S A. 97 (5): 2145–50. doi:10.1073/pnas.040569197. PMC 15768Freely accessible. PMID 10681437. 
  6. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  7. ^ a b c "Entrez Gene: ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12". 
  8. ^ a b Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Lett. 485 (2-3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164. 
  9. ^ a b c d Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065Freely accessible. PMID 12515866. 
  10. ^ Taya S, Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K (November 2001). "Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF". J. Cell Biol. 155 (5): 809–20. doi:10.1083/jcb.200106139. PMC 2150867Freely accessible. PMID 11724822. 
  11. ^ Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, Matsuya T, Inagaki S (September 2002). "Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors". Biochem. Biophys. Res. Commun. 297 (1): 32–7. doi:10.1016/S0006-291X(02)02122-8. PMID 12220504. 
  12. ^ Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ (July 2001). "Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA". J. Biol. Chem. 276 (29): 27145–51. doi:10.1074/jbc.M103565200. PMID 11373293. 

Further reading[edit]

External links[edit]