Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5gene.
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.
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