ARHGEF5

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ARHGEF5
Identifiers
Aliases ARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDs MGI: 1858952 HomoloGene: 66300 GeneCards: ARHGEF5
RNA expression pattern
PBB GE ARHGEF5 204765 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002861
NM_005435

NM_133674

RefSeq (protein)

NP_005426

NP_598435.1
NP_598435

Location (UCSC) Chr 7: 144.36 – 144.38 Mb Chr 6: 43.27 – 43.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.[3][4][5]

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T (Apr 1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Oncogene. 9 (4): 1057–63. PMID 8134109. 
  4. ^ Takai S, Chan AM, Yamada K, Miki T (Oct 1995). "Assignment of the human TIM proto-oncogene to 7q33→q35". Cancer Genet Cytogenet. 83 (1): 87–9. doi:10.1016/S0165-4608(95)00017-8. PMID 7656213. 
  5. ^ a b "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5". 

External links[edit]

Further reading[edit]