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Protein ARHGEF7 PDB 1by1.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases ARHGEF7, BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB, Rho guanine nucleotide exchange factor 7
External IDs MGI: 1860493 HomoloGene: 2895 GeneCards: ARHGEF7
RNA expression pattern
PBB GE ARHGEF7 202548 s at fs.png

PBB GE ARHGEF7 202547 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)
Location (UCSC) Chr 13: 111.11 – 111.31 Mb Chr 8: 11.73 – 11.84 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.[3][4][5]


Rho GTPase play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.[5]


ARHGEF7 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Oh WK, Yoo JC, Jo D, Song YH, Kim MG, Park D (Jul 1997). "Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion". Biochem Biophys Res Commun. 235 (3): 794–8. doi:10.1006/bbrc.1997.6875. PMID 9207241. 
  4. ^ Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L, Cerione RA (Oct 1998). "A novel regulator of p21-activated kinases". J Biol Chem. 273 (37): 23633–6. doi:10.1074/jbc.273.37.23633. PMID 9726964. 
  5. ^ a b "Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7". 
  6. ^ Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA (Aug 2003). "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): 119–23. doi:10.1016/s0014-5793(03)00853-6. PMID 12935897. 
  7. ^ Kim S, Ko J, Shin H, Lee JR, Lim C, Han JH, Altrock WD, Garner CC, Gundelfinger ED, Premont RT, Kaang BK, Kim E (Feb 2003). "The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo". J. Biol. Chem. 278 (8): 6291–300. doi:10.1074/jbc.M212287200. PMID 12473661. 
  8. ^ Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA (Aug 1999). "A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins". J. Biol. Chem. 274 (32): 22393–400. doi:10.1074/jbc.274.32.22393. PMID 10428811. 
  9. ^ a b c Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503. 

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