ARHGEF9

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ARHGEF9
Protein ARHGEF9 PDB 2dfk.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARHGEF9, COLLYBISTIN, EIEE8, HPEM-2, PEM-2, PEM2, Cdc42 guanine nucleotide exchange factor 9
External IDs MGI: 2442233 HomoloGene: 9053 GeneCards: ARHGEF9
RNA expression pattern
PBB GE ARHGEF9 203263 s at fs.png

PBB GE ARHGEF9 203264 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001173479
NM_001173480
NM_015185

NM_001033329
NM_001290384
NM_001290385

RefSeq (protein)

NP_001166950
NP_001166951
NP_001317424
NP_056000

Location (UCSC) Chr X: 63.63 – 63.81 Mb Chr X: 95.05 – 95.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.[3][4][5]

Function[edit]

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM][5]

Interactions[edit]

ARHGEF9 has been shown to interact with GPHN[6] and SMURF1.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Reid T, Bathoorn A, Ahmadian MR, Collard JG (Dec 1999). "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem. 274 (47): 33587–93. doi:10.1074/jbc.274.47.33587. PMID 10559246. 
  4. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477. 
  5. ^ a b "Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9". 
  6. ^ Kins S, Betz H, Kirsch J (2000). "Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin". Nat. Neurosci. 3 (1): 22–9. doi:10.1038/71096. PMID 10607391. 
  7. ^ Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008). "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. doi:10.1515/BC.2008.036. PMID 18208356. 

External links[edit]

Further reading[edit]