ARID3B

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ARID3B
Identifiers
Aliases ARID3B, BDP, DRIL2, AT-rich interaction domain 3B
External IDs MGI: 1930768 HomoloGene: 4721 GeneCards: ARID3B
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for ARID3B
Genomic location for ARID3B
Band 15q24.1 Start 74,541,177 bp[1]
End 74,598,131 bp[1]
RNA expression pattern
PBB GE ARID3B 218964 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001307939
NM_006465

NM_019689

RefSeq (protein)

NP_001294868
NP_006456

NP_062663

Location (UCSC) Chr 15: 74.54 – 74.6 Mb Chr 15: 57.79 – 57.84 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.[5]

Function[edit]

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.[5]

References[edit]

Further reading[edit]

  • Kortschak RD, Tucker PW, Saint R (Jun 2000). "ARID proteins come in from the desert". Trends in Biochemical Sciences. 25 (6): 294–9. PMID 10838570. doi:10.1016/S0968-0004(00)01597-8. 
  • Numata S, Claudio PP, Dean C, Giordano A, Croce CM (Aug 1999). "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product". Cancer Research. 59 (15): 3741–7. PMID 10446990. 
  • Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH (2016). "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports. 14 (3): 520–33. PMID 26776511. doi:10.1016/j.celrep.2015.12.064. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.