ARL1

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ARL1
Protein ARL1 PDB 1r4a.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARL1, ARFL1, ADP ribosylation factor like GTPase 1
External IDs MGI: 99436 HomoloGene: 20319 GeneCards: ARL1
RNA expression pattern
PBB GE ARL1 201658 at fs.png

PBB GE ARL1 201657 at fs.png

PBB GE ARL1 201659 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301068
NM_001177

NM_025859

RefSeq (protein)

NP_001168
NP_001287997

NP_080135.2
NP_080135

Location (UCSC) Chr 12: 101.39 – 101.41 Mb Chr 10: 88.73 – 88.74 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.[3]

Function[edit]

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.[3]

Interactions[edit]

ARL1 has been shown to interact with GOLGA4[4][5] and GOLGA1.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: ARL1 ADP-ribosylation factor-like 1". 
  4. ^ a b Lu L, Hong W (September 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566Freely accessible. PMID 12972563. 
  5. ^ Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027. 

External links[edit]

Further reading[edit]