ARL4A

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ARL4A
Identifiers
Aliases ARL4A, ARL4, ADP ribosylation factor like GTPase 4A
External IDs MGI: 99437 HomoloGene: 4194 GeneCards: ARL4A
RNA expression pattern
PBB GE ARL4A 205020 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_212460
NM_001037164
NM_001195396
NM_005738

NM_001039515
NM_007487

RefSeq (protein)

NP_001032241
NP_001182325
NP_005729
NP_997625

NP_001034604.1
NP_031513.1
NP_001034604
NP_031513

Location (UCSC) Chr 7: 12.69 – 12.69 Mb Chr 12: 40.01 – 40.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.[3]

Function[edit]

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.[3]

Interactions[edit]

ARL4A has been shown to interact with Karyopherin alpha 2.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A". 
  4. ^ Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193. 

Further reading[edit]

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. 
  • Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG (1999). "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal.". FEBS Lett. 456 (3): 384–8. doi:10.1016/S0014-5793(99)00759-0. PMID 10462049. 
  • Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (2001). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli.". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193. 
  • Hofmann I, Thompson A, Sanderson CM, Munro S (2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.". Curr. Biol. 17 (8): 711–6. doi:10.1016/j.cub.2007.03.007. PMID 17398095. 

External links[edit]