ARL6

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ARL6
Protein ARL6 PDB 2h57.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARL6, BBS3, RP55, ADP-ribosylation factor-like 6, ADP ribosylation factor like GTPase 6
External IDs MGI: 1927136 HomoloGene: 12960 GeneCards: 84100
RNA expression pattern
PBB GE ARL6 gnf1h00615 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278293
NM_032146
NM_177976

NM_019665

RefSeq (protein)

NP_001265222.1
NP_115522.1
NP_816931.1

NP_062639.3

Location (UCSC) Chr 3: 97.76 – 97.8 Mb Chr 16: 59.61 – 59.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene.[1][2][3]

The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. ARF proteins are important regulators of cellular traffic and are the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device that implements front-back communication from the N-terminus to the nucleotide-binding site. Studies of the mouse ortholog of this protein suggest an involvement in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been described.[3]

References[edit]

  1. ^ Chiang AP, Nishimura D, Searby C, Elbedour K, Carmi R, Ferguson AL, Secrist J, Braun T, Casavant T, Stone EM, Sheffield VC (Jul 2004). "Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)". Am J Hum Genet 75 (3): 475–84. doi:10.1086/423903. PMC 1182025. PMID 15258860. 
  2. ^ Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR (Sep 2004). "Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome". Nat Genet 36 (9): 989–93. doi:10.1038/ng1414. PMID 15314642. 
  3. ^ a b "Entrez Gene: ARL6 ADP-ribosylation factor-like 6". 

External links[edit]

Further reading[edit]