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Aliases ARL6IP5, DERP11, GTRAP3-18, JWA, PRAF3, addicsin, hp22, jmx, HSPC127, Yip6b, ADP ribosylation factor like GTPase 6 interacting protein 5
External IDs MGI: 1929501 HomoloGene: 4673 GeneCards: ARL6IP5
RNA expression pattern
PBB GE ARL6IP5 200761 s at fs.png

PBB GE ARL6IP5 200760 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 69.08 – 69.11 Mb Chr 6: 97.21 – 97.23 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

PRA1 family protein 3 is a protein that in humans is encoded by the ARL6IP5 gene.[3][4][5]


Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport.[5] The disruption of the mouse gene results in increased neuronal glutathione content, neuroprotection against oxidative stress and a better performance in motor/spatial learning and memory tests than wild-type mice.


ARL6IP5 has been shown to interact with SLC1A1.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (Mar 2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature. 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046. 
  4. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934Freely accessible. PMID 11042152. 
  5. ^ a b "Entrez Gene: ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5". 

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