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Protein ARPC1B PDB 1k8k.png
Aliases ARPC1B, ARC41, p40-ARC, p41-ARC, actin related protein 2/3 complex subunit 1B
External IDs MGI: 1343142 HomoloGene: 4179 GeneCards: ARPC1B
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 99.37 – 99.39 Mb Chr 5: 145.11 – 145.13 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Actin-related protein 2/3 complex subunit 1B is a protein that in humans is encoded by the ARPC1B gene.[3][4][5]


This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.[5]


ARPC1B has been shown to interact with PAK1.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Jul 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". The Journal of Cell Biology. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188Freely accessible. PMID 9230079. 
  4. ^ Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (Nov 1997). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". The Biochemical Journal. 328 ( Pt 1) (1): 105–12. PMC 1218893Freely accessible. PMID 9359840. 
  5. ^ a b "Entrez Gene: ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa". 
  6. ^ Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, Kumar R (Feb 2004). "p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate". EMBO Reports. 5 (2): 154–60. doi:10.1038/sj.embor.7400079. PMC 1298990Freely accessible. PMID 14749719. 

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