Serrate RNA effector molecule homolog

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SRRT
Identifiers
Aliases SRRT, ARS2, ASR2, serrate, serrate, RNA effector molecule
External IDs MGI: 1933527 HomoloGene: 9298 GeneCards: SRRT
RNA expression pattern
PBB GE ARS2 201679 at fs.png

PBB GE ARS2 201680 x at fs.png

PBB GE ARS2 222047 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001128852
NM_001128853
NM_001128854
NM_015908
NM_182800

NM_001109909
NM_001109910
NM_031405

RefSeq (protein)

NP_001122324
NP_001122325
NP_001122326
NP_056992

Location (UCSC) Chr 7: 100.88 – 100.89 Mb Chr 5: 137.3 – 137.31 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.[3]

The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding the SOX2 promoter and positively regulating its transcription.

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis.

References[edit]

Further reading[edit]