Serrate RNA effector molecule homolog

SRRT
Identifiers
Aliases	SRRT, ARS2, ASR2, serrate, serrate, RNA effector molecule
External IDs	OMIM: 614469 MGI: 1933527 HomoloGene: 9298 GeneCards: SRRT
Gene location (Human) Chr. Chromosome 7 (human) Band 7q22.1 Start 100,875,103 bp End 100,888,664 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 137,293,966 bp End 137,305,936 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve anterior pituitary right lobe of thyroid gland canal of the cervix left lobe of thyroid gland right uterine tube left uterine tube skin of abdomen spleen minor salivary glands Top expressed in bone marrow thymus islet of Langerhans ovary olfactory bulb spleen cerebellum cerebellar cortex hypothalamus lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding nucleic acid binding RNA binding Cellular component cytoplasm nucleus nucleoplasm protein-containing complex Biological process positive regulation of neurogenesis gene silencing cell population proliferation regulation of transcription, DNA-templated response to arsenic-containing substance transcription, DNA-templated neuronal stem cell population maintenance primary miRNA processing mRNA splicing, via spliceosome snRNA transcription by RNA polymerase II mRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51593 83701 Ensembl ENSG00000087087 ENSMUSG00000037364 UniProt Q9BXP5 Q99MR6 RefSeq (mRNA) NM_001128852 NM_001128853 NM_001128854 NM_015908 NM_182800 NM_001109909 NM_001109910 NM_031405 NM_001359602 RefSeq (protein) NP_001122324 NP_001122325 NP_001122326 NP_056992 NP_001103379 NP_001103380 NP_113582 NP_001346531 Location (UCSC) Chr 7: 100.88 – 100.89 Mb Chr 5: 137.29 – 137.31 Mb PubMed search
Wikidata
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Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.

The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding to the SOX2 promoter and positively regulating its transcription. It enables the binding activity of the mRNA cap binding complex and the adaptor activity of certain protein molecules. It can be found in the nucleoplasm and is part of the ribonucleoprotein complex. It is involved in cell cycle progression around the S phase.

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis and cerebral arteriopathy.

Further reading

• Rossman TG, Wang Z (1999). "Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis". Carcinogenesis. 20 (2): 311–6. doi:10.1093/carcin/20.2.311. PMID 10069470.
• Wilson MD, Riemer C, Martindale DW, et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Res. 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". J. Biochem. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.