ASAH2B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ASAH2B
Identifiers
Aliases ASAH2B, ASAH2L, bA449O16.3, bA98I6.3, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B, ASAH2C, N-acylsphingosine amidohydrolase 2B
External IDs GeneCards: ASAH2B
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ASAH2B
Genomic location for ASAH2B
Band 10q11.23 Start 50,739,318 bp[1]
End 50,816,495 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001079516
NM_001321957
NM_001321958
NM_001321959
NM_001321960

n/a

RefSeq (protein)

NP_001072984
NP_001308886
NP_001308887
NP_001308888
NP_001308889

n/a

Location (UCSC) Chr 10: 50.74 – 50.82 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.[3][4]

Clinical significance[edit]

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.[3]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000204147 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ a b Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805. 
  4. ^ Deloukas P, Earthrowl ME, Grafham DV, et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 

External links[edit]

Further reading[edit]

  • Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.