ASB2

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ASB2
Identifiers
Aliases ASB2, ASB-2, ankyrin repeat and SOCS box containing 2
External IDs MGI: 1929743 HomoloGene: 69202 GeneCards: ASB2
RNA expression pattern
PBB GE ASB2 gnf1h00212 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001202429
NM_016150

NM_023049

RefSeq (protein)

NP_001189358
NP_057234

NP_075536.1
NP_075536

Location (UCSC) Chr 14: 93.93 – 93.98 Mb Chr 12: 103.32 – 103.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.[3]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.[3]

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