ASCL2

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ASCL2
Identifiers
Aliases ASCL2, ASH2, HASH2, MASH2, bHLHa45, achaete-scute family bHLH transcription factor 2
External IDs MGI: 96920 HomoloGene: 3789 GeneCards: ASCL2
RNA expression pattern
PBB GE ASCL2 207607 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005170

NM_008554

RefSeq (protein)

NP_005161

NP_032580.2
NP_032580

Location (UCSC) Chr 11: 2.27 – 2.27 Mb Chr 7: 142.97 – 142.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Achaete-scute complex homolog 2 (Drosophila), also known as ASCL2, is an imprinted human gene.[3]

Function[edit]

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.[3]

Interactions[edit]

ASCL2 has been shown to interact with NCOA6[4] and RBBP5.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: ASCL2 achaete-scute complex homolog 2 (Drosophila)". 
  4. ^ a b Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670Freely accessible. PMID 12482968. 

External links[edit]

Further reading[edit]