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Activating transcription factor 1
Protein ATF1 PDB 1dh3.png
PDB rendering based on 1dh3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ATF1 ; EWS-ATF1; FUS/ATF-1; TREB36
External IDs OMIM123803 MGI1298366 HomoloGene3790 ChEMBL: 3255 GeneCards: ATF1 Gene
RNA expression pattern
PBB GE ATF1 222103 at tn.png
More reference expression data
Species Human Mouse
Entrez 466 11908
Ensembl ENSG00000123268 ENSMUSG00000023027
UniProt P18846 P81269
RefSeq (mRNA) NM_005171 NM_007497
RefSeq (protein) NP_005162 NP_031523
Location (UCSC) Chr 12:
50.76 – 50.82 Mb
Chr 15:
100.23 – 100.26 Mb
PubMed search [1] [2]

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.[1]

Clinical significance[edit]

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.[2][1]

See also[edit]


ATF1 has been shown to interact with:


  1. ^ a b "Entrez Gene: ATF1 activating transcription factor 1". 
  2. ^ Zucman J, Delattre O, Desmaze C, Epstein AL, Stenman G, Speleman F, Fletchers CD, Aurias A, Thomas G (November 1993). "EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts". Nat Genet 4 (4): 341–5. doi:10.1038/ng0893-341. PMID 8401579. 
  3. ^ Houvras Y, Benezra M, Zhang H, Manfredi JJ, Weber BL, Licht JD (November 2000). "BRCA1 physically and functionally interacts with ATF1". J. Biol. Chem. 275 (46): 36230–7. doi:10.1074/jbc.M002539200. PMID 10945975. 
  4. ^ a b Yamaguchi Y, Wada T, Suzuki F, Takagi T, Hasegawa J, Handa H (August 1998). "Casein kinase II interacts with the bZIP domains of several transcription factors". Nucleic Acids Res. 26 (16): 3854–61. doi:10.1093/nar/26.16.3854. PMC 147779. PMID 9685505. 
  5. ^ Fujimura Y, Ohno T, Siddique H, Lee L, Rao VN, Reddy ES (January 1996). "The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator". Oncogene 12 (1): 159–67. PMID 8552387. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.