ATF6

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ATF6
Identifiers
Aliases ATF6, ATF6A, ACHM7, activating transcription factor 6
External IDs MGI: 1926157 HomoloGene: 32015 GeneCards: 22926
Genetically Related Diseases
Disease Name References
Parkinson's disease
RNA expression pattern
PBB GE ATF6 203952 at tn.png

PBB GE ATF6 217550 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007348

NM_001081304

RefSeq (protein)

NP_031374.2

NP_001074773.1

Location (UCSC) Chr 1: 161.77 – 161.96 Mb Chr 1: 170.7 – 170.87 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[1][2][3] and is involved in the unfolded protein response.

Function[edit]

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[4] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also[edit]

Interactions[edit]

ATF6 has been shown to interact with YY1[5] and Serum response factor.[2]

References[edit]

  1. ^ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827. 
  2. ^ a b Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374. 
  3. ^ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. 92 (7): 2720–5. doi:10.1210/jc.2006-2280. PMID 17440018. 
  4. ^ "Entrez Gene: ATF6 activating transcription factor 6". 
  5. ^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. PMC 85959. PMID 10866666. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.