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Activating transcription factor 6
Symbols ATF6 ; ATF6A
External IDs OMIM605537 MGI1926157 HomoloGene32015 GeneCards: ATF6 Gene
RNA expression pattern
PBB GE ATF6 203952 at tn.png
PBB GE ATF6 217550 at tn.png
More reference expression data
Species Human Mouse
Entrez 22926 226641
Ensembl ENSG00000118217 ENSMUSG00000026663
UniProt P18850 F6VAN0
RefSeq (mRNA) NM_007348 NM_001081304
RefSeq (protein) NP_031374 NP_001074773
Location (UCSC) Chr 1:
161.77 – 161.96 Mb
Chr 1:
170.7 – 170.87 Mb
PubMed search [1] [2]

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[1][2][3] and is involved in the unfolded protein response.


ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[4] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also[edit]


ATF6 has been shown to interact with YY1[5] and Serum response factor.[2]


  1. ^ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827. 
  2. ^ a b Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374. 
  3. ^ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. 92 (7): 2720–5. doi:10.1210/jc.2006-2280. PMID 17440018. 
  4. ^ "Entrez Gene: ATF6 activating transcription factor 6". 
  5. ^ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. PMC 85959. PMID 10866666. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.