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AliasesATF7, ATFA, activating transcription factor 7
External IDsOMIM: 606371 MGI: 2443472 HomoloGene: 4994 GeneCards: ATF7
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for ATF7
Genomic location for ATF7
Band12q13.13Start53,507,856 bp[1]
End53,626,410 bp[1]
RNA expression pattern
PBB GE ATF7 206684 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 12: 53.51 – 53.63 MbChr 15: 102.53 – 102.63 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.[5][6][7]


In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1.[6] This ATF-7 is actually ATF5 and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.")[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170653 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000099083 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gaire M, Chatton B, Kedinger C (Aug 1990). "Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells". Nucleic Acids Res. 18 (12): 3467–73. doi:10.1093/nar/18.12.3467. PMC 330998. PMID 1694576.
  6. ^ a b c Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J Biol Chem. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933.
  7. ^ "Entrez Gene: ATF7 activating transcription factor 7".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.