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Activating transcription factor 7
Symbols ATF7 ; ATFA
External IDs OMIM606371 MGI2443472 HomoloGene4994 GeneCards: ATF7 Gene
RNA expression pattern
PBB GE ATF7 206684 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11016 223922
Ensembl ENSG00000170653 ENSMUSG00000099083
UniProt P17544 Q8R0S1
RefSeq (mRNA) NM_001130059 NM_001310066
RefSeq (protein) NP_001123532 NP_001296995
Location (UCSC) Chr 12:
53.51 – 53.63 Mb
Chr 15:
102.53 – 102.63 Mb
PubMed search [1] [2]

Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.[1][2][3]


In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1.[2] This ATF-7 is actually ATF5 and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.")[2]


  1. ^ Gaire M, Chatton B, Kedinger C (Aug 1990). "Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells". Nucleic Acids Res 18 (12): 3467–73. doi:10.1093/nar/18.12.3467. PMC 330998. PMID 1694576. 
  2. ^ a b c Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J Biol Chem 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933. 
  3. ^ "Entrez Gene: ATF7 activating transcription factor 7". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.