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Autophagy related 5
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ATG5 ; APG5; APG5-LIKE; APG5L; ASP; hAPG5
External IDs OMIM604261 MGI1277186 HomoloGene3566 GeneCards: ATG5 Gene
RNA expression pattern
PBB GE ATG5 210639 s at tn.png
PBB GE ATG5 202511 s at tn.png
PBB GE ATG5 202512 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9474 11793
Ensembl ENSG00000057663 ENSMUSG00000038160
UniProt Q9H1Y0 Q99J83
RefSeq (mRNA) NM_001286106 NM_053069
RefSeq (protein) NP_001273035 NP_444299
Location (UCSC) Chr 6:
106.18 – 106.33 Mb
Chr 10:
44.27 – 44.36 Mb
PubMed search [1] [2]

Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene.[1][2][3][4] It is an E3 ubiquitin ligase which is necessary for autophagy due to its role in autophagosome elongation. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II.


  1. ^ Hammond EM, Brunet CL, Johnson GD, Parkhill J, Milner AE, Brady G, Gregory CD, Grand RJ (May 1998). "Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast". FEBS Lett 20 (3): 391–5. doi:10.1016/S0014-5793(98)00266-X. PMID 9563500. 
  2. ^ Baumann P, Cech TR (May 2001). "Pot1, the putative telomere end-binding protein in fission yeast and humans". Science 292 (5519): 1171–5. doi:10.1126/science.1060036. PMID 11349150. 
  3. ^ Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Oshumi Y, Jung YK (May 2005). "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death". J Biol Chem 280 (21): 20722–9. doi:10.1074/jbc.M413934200. PMID 15778222. 
  4. ^ "Entrez Gene: ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae)". 

Further reading[edit]