ATG5

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ATG5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5, autophagy related 5
External IDs MGI: 1277186 HomoloGene: 3566 GeneCards: 9474
Genetically Related Diseases
Disease Name References
Rheumatoid Arthritis
RNA expression pattern
PBB GE ATG5 202511 s at tn.png

PBB GE ATG5 202512 s at tn.png

PBB GE ATG5 210639 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286106
NM_001286107
NM_001286108
NM_001286111
NM_004849

NM_053069
NM_001314013

RefSeq (protein)

NP_001273035.1
NP_001273036.1
NP_001273037.1
NP_001273040.1
NP_004840.1

NP_001300942.1
NP_444299.1

Location (UCSC) Chr 6: 106.18 – 106.33 Mb Chr 10: 44.27 – 44.36 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene.[4][5][6][7] It is an E3 ubiquitin ligase which is necessary for autophagy due to its role in autophagosome elongation. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II.


References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_7148&geneId=196404". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Hammond EM, Brunet CL, Johnson GD, Parkhill J, Milner AE, Brady G, Gregory CD, Grand RJ (May 1998). "Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast". FEBS Lett. 20 (3): 391–5. doi:10.1016/S0014-5793(98)00266-X. PMID 9563500. 
  5. ^ Baumann P, Cech TR (May 2001). "Pot1, the putative telomere end-binding protein in fission yeast and humans". Science. 292 (5519): 1171–5. doi:10.1126/science.1060036. PMID 11349150. 
  6. ^ Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Oshumi Y, Jung YK (May 2005). "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death". J Biol Chem. 280 (21): 20722–9. doi:10.1074/jbc.M413934200. PMID 15778222. 
  7. ^ "Entrez Gene: ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae)". 

Further reading[edit]