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ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Symbols ATP12A ; ATP1AL1
External IDs OMIM182360 MGI1926943 HomoloGene68197 ChEMBL: 2933 GeneCards: ATP12A Gene
EC number
RNA expression pattern
PBB GE ATP12A 207367 at tn.png
More reference expression data
Species Human Mouse
Entrez 479 192113
Ensembl ENSG00000075673 ENSMUSG00000022229
UniProt P54707 Q9Z1W8
RefSeq (mRNA) NM_001185085 NM_138652
RefSeq (protein) NP_001172014 NP_619593
Location (UCSC) Chr 13:
24.68 – 24.71 Mb
Chr 14:
56.37 – 56.39 Mb
PubMed search [1] [2]

ATPase, H+/K+ transporting, nongastric, alpha polypeptide (also known as ATP12A) is a protein that in humans is encoded by the ATP12A gene.[1][2][3]


The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.[1]


  1. ^ a b "Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide". 
  2. ^ Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794. 
  3. ^ Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249. 

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