ATP1A4

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ATP1A4
Identifiers
Aliases ATP1A4, ATP1A1, ATP1AL2, ATPase Na+/K+ transporting subunit alpha 4
External IDs MGI: 1351335 HomoloGene: 113769 GeneCards: 480
RNA expression pattern
PBB GE ATP1A4 gnf1h01969 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001734
NM_144699

NM_013734

RefSeq (protein)

NP_001001734.1
NP_653300.2

NP_038762.1

Location (UCSC) Chr 1: 160.15 – 160.19 Mb Chr 1: 172.22 – 172.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.[1][2][3]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

References[edit]

  1. ^ Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC (May 1991). "A detailed multipoint gene map of chromosome 1q". Genomics 8 (1): 13–21. doi:10.1016/0888-7543(90)90220-O. PMID 1981991. 
  2. ^ Shull MM, Lingrel JB (Jul 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563. 
  3. ^ a b "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide". 

Further reading[edit]