ATP1B1

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ATP1B1
Identifiers
Aliases ATP1B1, ATP1B, ATPase Na+/K+ transporting subunit beta 1
External IDs MGI: 88108 HomoloGene: 37509 GeneCards: 481
RNA expression pattern
PBB GE ATP1B1 201242 s at tn.png

PBB GE ATP1B1 201243 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001677
NM_001001787

NM_009721

RefSeq (protein)

NP_001668.1

NP_033851.1

Location (UCSC) Chr 1: 169.11 – 169.13 Mb Chr 1: 164.44 – 164.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.[3]

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

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