ATP2A3

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ATP2A3
Identifiers
Aliases ATP2A3, SERCA3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
External IDs MGI: 1194503 HomoloGene: 69131 GeneCards: 489
RNA expression pattern
PBB GE ATP2A3 207521 s at tn.png

PBB GE ATP2A3 207522 s at tn.png

PBB GE ATP2A3 213036 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001163336
NM_001163337
NM_016745

RefSeq (protein)

NP_001156809.1
NP_058025.2

Location (UCSC) Chr 17: 3.92 – 3.96 Mb Chr 11: 72.96 – 72.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.[1][2]

This gene encodes one of the SERCA Ca2+-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.[2]

References[edit]

  1. ^ Dode L, Wuytack F, Kools PF, Baba-Aissa F, Raeymaekers L, Brike F, van de Ven WJ, Casteels R (Nov 1996). "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene". Biochem J 318 (2): 689–99. PMC 1217674. PMID 8809064. 
  2. ^ a b "Entrez Gene: ATP2A3 ATPase, Ca++ transporting, ubiquitous". 

Further reading[edit]