From Wikipedia, the free encyclopedia
Jump to: navigation, search
ATPase, Ca++ transporting, plasma membrane 3
Symbols ATP2B3 ; CFAP39; CLA2; OPCA; PMCA3; PMCA3a; SCAX1
External IDs OMIM300014 MGI1347353 HomoloGene123775 GeneCards: ATP2B3 Gene
EC number
RNA expression pattern
PBB GE ATP2B3 207026 s at tn.png
PBB GE ATP2B3 215911 x at tn.png
More reference expression data
Species Human Mouse
Entrez 492 320707
Ensembl ENSG00000067842 ENSMUSG00000031376
UniProt Q16720 A2ALL9
RefSeq (mRNA) NM_001001344 NM_177236
RefSeq (protein) NP_001001344 NP_796210
Location (UCSC) Chr X:
153.52 – 153.58 Mb
Chr X:
73.5 – 73.57 Mb
PubMed search [1] [2]

Plasma membrane calcium-transporting ATPase 3 is an enzyme that in humans is encoded by the ATP2B3 gene.[1][2]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]


  1. ^ Wang MG, Yi H, Hilfiker H, Carafoli E, Strehler EE, McBride OW (Jun 1994). "Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26→p25 and Xq28, respectively". Cytogenet Cell Genet 67 (1): 41–5. doi:10.1159/000133794. PMID 8187550. 
  2. ^ a b "Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3". 

Further reading[edit]