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ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Protein ATP5C1 PDB 1bmf.png
PDB rendering based on 1bmf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ATP5C1 ; ATP5C; ATP5CL1
External IDs OMIM108729 MGI1261437 HomoloGene3792 GeneCards: ATP5C1 Gene
EC number
RNA expression pattern
PBB GE ATP5C1 205711 x at tn.png
PBB GE ATP5C1 208870 x at tn.png
PBB GE ATP5C1 213366 x at tn.png
More reference expression data
Species Human Mouse
Entrez 509 11949
Ensembl ENSG00000165629 ENSMUSG00000025781
UniProt P36542 Q91VR2
RefSeq (mRNA) NM_001001973 NM_001112738
RefSeq (protein) NP_001001973 NP_001106209
Location (UCSC) Chr 10:
7.79 – 7.81 Mb
Chr 2:
10.06 – 10.08 Mb
PubMed search [1] [2]

The human ATP5C1 gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.[1][2][3]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes adenosine triphosphate(ATP) synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation.

ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core.

Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.[3]


  1. ^ Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL (Jun 1994). "Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier". Hum Genet 93 (5): 600–2. doi:10.1007/bf00202832. PMID 8168843. 
  2. ^ Matsuda C, Endo H, Ohta S, Kagawa Y (Dec 1993). "Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing". J Biol Chem 268 (33): 24950–8. PMID 8227057. 
  3. ^ a b "Entrez Gene: ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1". 

Further reading[edit]