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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
Symbols ATP5I ; ATP5K
External IDs OMIM601519 MGI106636 HomoloGene136813 IUPHAR: 805 GeneCards: ATP5I Gene
EC number
RNA expression pattern
PBB GE ATP5I 209492 x at tn.png
PBB GE ATP5I 207335 x at tn.png
More reference expression data
Species Human Mouse
Entrez 521 11958
Ensembl ENSG00000169020 ENSMUSG00000050856
UniProt P56385 Q06185
RefSeq (mRNA) NM_007100 NM_007507
RefSeq (protein) NP_009031 NP_031533
Location (UCSC) Chr 4:
0.67 – 0.67 Mb
Chr 5:
108.43 – 108.43 Mb
PubMed search [1] [2]
ATP synthase E chain
Symbol ATP-synt_E
Pfam PF05680
InterPro IPR008386
SCOP 1e79

ATP synthase subunit e, mitochondrial is an enzyme that in humans is encoded by the ATP5I gene.[1][2]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F0 seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the F0 complex.[2]

In yeast, the FO complex E subunit appears to play an important role in supporting F-ATPase dimerisation. This subunit is anchored to the inner mitochondrial membrane via its N-terminal region, which is involved in stabilising subunits G and K of the FO complex. The C-terminal region of subunit E is hydrophilic, protruding into the intermembrane space where it can also help stabilise the F-ATPase dimer complex.[3]


  1. ^ Swartz DA, Park EI, Visek WJ, Kaput J (Oct 1996). "The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation". J Biol Chem 271 (34): 20942–8. doi:10.1074/jbc.271.34.20942. PMID 8702853. 
  2. ^ a b "Entrez Gene: ATP5I ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E". 
  3. ^ Everard-Gigot V, Dunn CD, Dolan BM, Brunner S, Jensen RE, Stuart RA (February 2005). "Functional analysis of subunit e of the F1Fo-ATP synthase of the yeast Saccharomyces cerevisiae: importance of the N-terminal membrane anchor region". Eukaryotic Cell 4 (2): 346–55. doi:10.1128/EC.4.2.346-355.2005. PMC 549337. PMID 15701797. 

Further reading[edit]

This article incorporates text from the public domain Pfam and InterPro IPR008386