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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
Symbols ATP5L ; ATP5JG
External IDs HomoloGene86074 GeneCards: ATP5L Gene
EC number
RNA expression pattern
PBB GE ATP5L 208745 at tn.png
PBB GE ATP5L 207573 x at tn.png
PBB GE ATP5L 208746 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10632 27425
Ensembl ENSG00000167283 ENSMUSG00000038717
UniProt O75964 Q9CPQ8
RefSeq (mRNA) NM_006476 NM_013795
RefSeq (protein) NP_006467 NP_038823
Location (UCSC) Chr 11:
118.27 – 118.3 Mb
Chr 5:
24.58 – 24.58 Mb
PubMed search [1] [2]
Symbol ATP-synt_G
Pfam PF04718
InterPro IPR006808

ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5L gene.[1][2][3]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F0 seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the F0 complex.[3]

The function of subunit G is currently unknown. There is no counterpart in chloroplast or bacterial F-ATPases identified so far.[4]


  1. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. 
  2. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. 
  3. ^ a b "Entrez Gene: ATP5L ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G". 
  4. ^ Collinson IR, Runswick MJ, Buchanan SK, Fearnley IM, Skehel JM, van Raaij MJ, Griffiths DE, Walker JE (June 1994). "Fo membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase". Biochemistry 33 (25): 7971–8. doi:10.1021/bi00191a026. PMID 8011660. 

Further reading[edit]

This article incorporates text from the public domain Pfam and InterPro IPR006808