ATP5L

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ATP5L
Identifiers
Aliases ATP5L, ATP5JG, ATP synthase, H+ transporting, mitochondrial Fo complex subunit G
External IDs MGI: 1351597 HomoloGene: 86074 GeneCards: ATP5L
RNA expression pattern
PBB GE ATP5L 208746 x at fs.png

PBB GE ATP5L 207573 x at fs.png

PBB GE ATP5L 208745 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006476

NM_013795

RefSeq (protein)

NP_006467

NP_038823.2
NP_038823

Location (UCSC) Chr 11: 118.4 – 118.43 Mb Chr 9: 44.91 – 44.92 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse
ATP-synt_G
Identifiers
Symbol ATP-synt_G
Pfam PF04718
InterPro IPR006808

ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5L gene.[3][4][5]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F0 seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the F0 complex.[5]

The function of subunit G is currently unknown. There is no counterpart in chloroplast or bacterial F-ATPases identified so far.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072Freely accessible. PMID 11230166. 
  4. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934Freely accessible. PMID 11042152. 
  5. ^ a b "Entrez Gene: ATP5L ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G". 
  6. ^ Collinson IR, Runswick MJ, Buchanan SK, Fearnley IM, Skehel JM, van Raaij MJ, Griffiths DE, Walker JE (June 1994). "Fo membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase". Biochemistry. 33 (25): 7971–8. doi:10.1021/bi00191a026. PMID 8011660. 

External links[edit]

Further reading[edit]


This article incorporates text from the public domain Pfam and InterPro IPR006808