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ATPase, H+ transporting, lysosomal accessory protein 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ATP6AP2 ; APT6M8-9; ATP6IP2; ATP6M8-9; ELDF10; HT028; M8-9; MRXE; MRXSH; MSTP009; PRR; RENR; XMRE; XPDS
External IDs OMIM300556 MGI1917745 HomoloGene38097 GeneCards: ATP6AP2 Gene
RNA expression pattern
PBB GE ATP6AP2 201443 s at tn.png
PBB GE ATP6AP2 201444 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10159 70495
Ensembl ENSG00000182220 ENSMUSG00000031007
UniProt O75787 Q9CYN9
RefSeq (mRNA) NM_005765 NM_027439
RefSeq (protein) NP_005756 NP_081715
Location (UCSC) Chr X:
40.58 – 40.61 Mb
Chr X:
12.59 – 12.62 Mb
PubMed search [1] [2]

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[1][2][3]


The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.[4]

This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[3]


  1. ^ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572. 
  2. ^ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis 7: 234–9. PMID 11590366. 
  3. ^ a b "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2". 
  4. ^ Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. doi:10.1172/JCI14276. PMC 150992. PMID 12045255. 

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