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ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
Symbols ATP6V1B2 ; ATP6B1B2; ATP6B2; HO57; VATB; VPP3; Vma2
External IDs OMIM606939 MGI109618 HomoloGene1279 ChEMBL: 5641 GeneCards: ATP6V1B2 Gene
EC number
RNA expression pattern
PBB GE ATP6V1B2 201089 at tn.png
More reference expression data
Species Human Mouse
Entrez 526 11966
Ensembl ENSG00000147416 ENSMUSG00000006273
UniProt P21281 P62814
RefSeq (mRNA) NM_001693 NM_007509
RefSeq (protein) NP_001684 NP_031535
Location (UCSC) Chr 8:
20.2 – 20.23 Mb
Chr 8:
69.09 – 69.11 Mb
PubMed search [1] [2]

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.[1][2][3]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.[3]

In melanocytic cells ATP6V1B2 gene expression may be regulated by MITF.[4]


  1. ^ Bernasconi P, Rausch T, Struve I, Morgan L, Taiz L (Nov 1990). "An mRNA from human brain encodes an isoform of the B subunit of the vacuolar H(+)-ATPase". J Biol Chem 265 (29): 17428–31. PMID 2145275. 
  2. ^ Smith AN, Lovering RC, Futai M, Takeda J, Brown D, Karet FE (Oct 2003). "Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes". Mol Cell 12 (4): 801–3. doi:10.1016/S1097-2765(03)00397-6. PMID 14580332. 
  3. ^ a b "Entrez Gene: ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

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