ATP6V1G2

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ATP6V1G2
Identifiers
AliasesATP6V1G2, ATP6G, ATP6G2, NG38, VMA10, ATPase H+ transporting V1 subunit G2
External IDsMGI: 1913487 HomoloGene: 41518 GeneCards: ATP6V1G2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for ATP6V1G2
Genomic location for ATP6V1G2
Band6p21.33Start31,544,462 bp[1]
End31,548,427 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138282
NM_001204078
NM_130463

NM_023179
NM_001347351

RefSeq (protein)

NP_001191007
NP_569730
NP_612139

NP_001334280
NP_075668

Location (UCSC)Chr 6: 31.54 – 31.55 MbChr 17: 35.23 – 35.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

V-type proton ATPase subunit G 2 is an enzyme that in humans is encoded by the ATP6V1G2 gene.[5][6]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c double prime, and d.

Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes, or alternatively spliced transcript variants. This encoded protein is one of three V1 domain G subunit proteins. This gene had previous gene symbols of ATP6G and ATP6G2. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

References[edit]

  1. ^ a b c ENSG00000234920, ENSG00000206445, ENSG00000230900, ENSG00000213760, ENSG00000234668, ENSG00000226850 GRCh38: Ensembl release 89: ENSG00000227587, ENSG00000234920, ENSG00000206445, ENSG00000230900, ENSG00000213760, ENSG00000234668, ENSG00000226850 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024403 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Neville MJ, Campbell RD (May 1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC". J Immunol. 162 (8): 4745–54. PMID 10202016.
  6. ^ a b "Entrez Gene: ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2".

External links[edit]

Further reading[edit]