ATP6V1G3

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ATP6V1G3
Identifiers
Aliases ATP6V1G3, ATP6G3, Vma10, ATPase H+ transporting V1 subunit G3
External IDs MGI: 2450548 HomoloGene: 13630 GeneCards: 127124
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_133262
NM_133326
NM_001320218

NM_177397

RefSeq (protein)

NP_573569.1
NP_579872.1

NP_796371.1

Location (UCSC) Chr 1: 198.52 – 198.54 Mb Chr 1: 138.27 – 138.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.[1][2]

Function[edit]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.[2]

References[edit]

  1. ^ Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887. 
  2. ^ a b "Entrez Gene: ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3". 

Further reading[edit]