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Aliases ATP8B3, ATPIK, ATPase phospholipid transporting 8B3
External IDs MGI: 1914581 HomoloGene: 19034 GeneCards: 148229
Genetically Related Diseases
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 1.78 – 1.81 Mb Chr 10: 80.52 – 80.54 Mb
PubMed search [2] [3]
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The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.[4]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[4]


Further reading[edit]

  • Halleck, M. S.; Lawler Jr., J. F.; Blackshaw, S.; Gao, L.; Nagarajan, P.; Hacker, C.; Pyle, S.; Newman, J. T.; Nakanishi, Y.; Ando, H.; Weinstock, D.; Williamson, P.; Schlegel, R. A. (1999). "Differential expression of putative transbilayer amphipath transporters". Physiological genomics. 1 (3): 139–150. PMID 11015572. 
  • Harris, M. J.; Arias, I. M. (2003). "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body". Biochimica et Biophysica Acta. 1633 (2): 127–131. doi:10.1016/S1388-1981(03)00107-0. PMID 12880872. 
  • Fries, A. S.; Svendsen, O. (1978). "Studies on Tyzzer's disease in rats". Laboratory animals. 12 (1): 1–4. PMID 146761. 
  • Scott, L. J.; Muglia, P.; Kong, X. Q.; Guan, W.; Flickinger, M.; Upmanyu, R.; Tozzi, F.; Li, J. Z.; Burmeister, M.; Absher, D.; Thompson, R. C.; Francks, C.; Meng, F.; Antoniades, A.; Southwick, A. M.; Schatzberg, A. F.; Bunney, W. E.; Barchas, J. D.; Jones, E. G.; Day, R.; Matthews, K.; McGuffin, P.; Strauss, J. S.; Kennedy, J. L.; Middleton, L.; Roses, A. D.; Watson, S. J.; Vincent, J. B.; Myers, R. M.; Farmer, A. E. (2009). "Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry". Proceedings of the National Academy of Sciences. 106 (18): 7501–7506. doi:10.1073/pnas.0813386106. PMC 2678639free to read. PMID 19416921. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.