ATPAF1

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ATPAF1
Identifiers
Aliases ATPAF1, ATP11, ATP11p, ATP synthase mitochondrial F1 complex assembly factor 1
External IDs MGI: 2180560 HomoloGene: 41492 GeneCards: ATPAF1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022745
NM_001042546
NM_001243728
NM_001256418

NM_181040

RefSeq (protein)

NP_001036011
NP_001230657
NP_001243347
NP_073582

n/a

Location (UCSC) Chr 1: 46.63 – 46.67 Mb Chr 4: 115.78 – 115.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

ATP synthase mitochondrial F1 complex assembly factor 1, also known as ATP11 homolog, is a protein that in humans is encoded by the ATPAF1 gene.[3][4]

Function[edit]

This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 beta subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. Alternatively spliced transcript variants have been identified, but the biological validity of some of these variants has not been determined.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: ATP synthase mitochondrial F1 complex assembly factor 1". 
  4. ^ Wang ZG, White PS, Ackerman SH (August 2001). "Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria". J. Biol. Chem. 276 (33): 30773–8. doi:10.1074/jbc.M104133200. PMID 11410595. 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.